gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-TROP2 ADC binds TROP2, is internalized, and releases SN-38, a topoisomerase I inhibitor, causing DNA damage (Topo I–DNA complex stabilization), replication arrest, and apoptosis; may also cause a bystander effect.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein; recognized by hRS7 antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06793332
disease_id_num_tar_ref
1917
drug_id_num_tar_ref
5106