gene_symbol
MAGEA1
hgnc_id
HGNC:6796
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-engineered autologous T cells recognize the MAGE-A1 peptide–HLA-A*02:01 complex via TCR/CD3 and directly kill target cells through CTL effector mechanisms (perforin/granzyme release and Fas–FasL-mediated apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognition of a specific MAGE-A1-derived peptide in the HLA-A*02:01 pMHC complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5107