gene_symbol
MAGEA1
hgnc_id
HGNC:6796
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-engineered autologous T cells bind the MAGE-A1 peptide presented by HLA-C*07:02 on tumor cells, activating TCR/CD3 signaling and inducing CTL effector killing via perforin/granzyme (and Fas/FasL) apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-C*07:02-restricted peptide–HLA (pMHC) target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5108