gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
other
cytotoxicity
NO
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells directly kill only cells presenting the MAGE-A1 peptide in HLA-C*07:02 via TCR/CD3 activation and perforin/granzyme-mediated apoptosis; HLA-C*07:02 alone is not sufficient for targeting.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-specific restriction; presents the MAGE-A1 epitope recognized by the TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5108