gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-engineered autologous T cells recognize the HPV16 E7 peptide presented by HLA-A*02:01 on tumor cells via TCR/CD3, leading to direct killing through perforin/granzyme (and Fas/FasL) cytotoxic pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognizes HPV16 E7 peptide presented by HLA-A*02:01 (peptide–HLA complex)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5109