gene_symbol
PRAME
hgnc_id
HGNC:9336
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-engineered autologous T cells recognize the PRAME peptide–HLA-A*02:01 complex via their TCR/CD3, activate, and directly kill target cells through perforin/granzyme-mediated cytolysis (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA class I peptide–HLA complex (allele HLA-A*02:01); exact PRAME epitope not specified
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5110