gene_symbol
MAGEC2
hgnc_id
HGNC:13574
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells bind the MAGE-C2 peptide presented by HLA-B*07:02 on tumor cells, triggering TCR/CD3 activation and perforin/granzyme (and Fas/FasL)–mediated killing of antigen-positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized as a peptide presented by HLA-B*07:02 (peptide–HLA complex)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5112