gene_symbol
HLA-B
hgnc_id
HGNC:4932
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the MAGE-C2 peptide presented by HLA-B*07:02, triggering TCR/CD3 activation and perforin/granzyme-mediated killing. HLA-B*07:02 expression alone is not sufficient for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Restriction element required for TCR recognition of MAGE-C2 peptide
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5112