gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HLA-A*02:01 alone is not targeted. Killing occurs only when tumor cells present the MAGE-A4 peptide on HLA-A*02:01, which is recognized by the engineered TCR, triggering T-cell cytotoxicity (perforin/granzyme).
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presents MAGE-A4 peptide as part of the pMHC target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05973487
disease_id_num_tar_ref
1918
drug_id_num_tar_ref
5113