gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Disitamab vedotin targets HER2 on the cell surface, is internalized, and releases MMAE, which binds beta-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis; beta-tubulin expression alone does not trigger targeting.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
vinca-site binding target of MMAE payload; inhibits tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145308
disease_id_num_tar_ref
1920
drug_id_num_tar_ref
5115