gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-binding ADC is internalized and releases the topoisomerase I inhibitor deruxtecan, causing DNA damage/replication block, cell-cycle arrest and apoptosis; it also mediates ADCC and a bystander killing effect.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; antibody binding triggers internalization and ADCC; enables DXd release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145308
disease_id_num_tar_ref
1920
drug_id_num_tar_ref
5116