gene_symbol
NTRK1
hgnc_id
HGNC:8031
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ATP-competitive inhibition of TRKA blocks neurotrophin-TRK signaling (e.g., MAPK/ERK, PI3K/AKT), leading to growth arrest and apoptosis in NTRK-driven cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ATP-competitive inhibition at kinase domain active site
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145308
disease_id_num_tar_ref
1920
drug_id_num_tar_ref
5120