gene_symbol
NTRK3
hgnc_id
HGNC:8033
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Larotrectinib directly inhibits TRKC (NTRK3) kinase activity (ATP-competitive), blocking neurotrophin–TRK signaling (e.g., MAPK/ERK, PI3K/AKT) and inducing growth arrest and apoptosis in TRK-dependent tumor cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ATP-competitive inhibition at kinase domain active site
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145308
disease_id_num_tar_ref
1920
drug_id_num_tar_ref
5120