gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Sacituzumab govitecan targets TROP2 on tumor cells; after internalization it releases SN-38, which inhibits topoisomerase I in those TROP2+ cells, causing DNA damage and apoptosis (with possible bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (SN-38) stabilizes TOP1–DNA complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145308
disease_id_num_tar_ref
1920
drug_id_num_tar_ref
5131