gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Selective BH3-mimetic inhibition of BCL-2 in target cells releases pro-apoptotic proteins, activates BAX/BAK, induces mitochondrial outer membrane permeabilization, caspase activation, and apoptotic cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-binding groove of anti-apoptotic BCL-2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06634589
disease_id_num_tar_ref
214
drug_id_num_tar_ref
583