gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cells are not targeted via DNA topoisomerase I expression. The ADC binds TROP-2, is internalized, and releases tirumotecan, which inhibits TOP1 to block DNA replication and induce apoptosis; a bystander effect may occur.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload (tirumotecan) inhibits TOP1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145308
disease_id_num_tar_ref
1920
drug_id_num_tar_ref
5132