gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD47 blockade removes SIRPa-mediated 'don't eat me' signaling, enabling macrophage phagocytosis of CD47+ cells and promoting downstream T-cell–mediated killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
SIRPα-Fc decoy receptor; blocks CD47–SIRPα interaction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05787639
disease_id_num_tar_ref
1924
drug_id_num_tar_ref
5155