gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on target cells and engages Fcγ receptor–bearing immune cells (e.g., NK cells) to mediate antibody‑dependent cellular cytotoxicity, leading to lysis of HER2+ cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds domain IV of the HER2 extracellular domain; engagement can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05062889
disease_id_num_tar_ref
1945
drug_id_num_tar_ref
5210