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gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3 epsilon is on T cells; mosunetuzumab binds CD3 to recruit/activate T cells, which then kill CD20-positive B cells via T-cell cytotoxicity (perforin/granzyme). CD3-positive cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the CD3ε chain within the TCR-CD3 complex on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06634589
disease_id_num_tar_ref
214
drug_id_num_tar_ref
585