gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CLDN18.2 ADC binds CLDN18.2 on target cells, is internalized, and releases a topoisomerase I–inhibitor payload that induces DNA damage and apoptosis, with potential bystander killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform of claudin-18; tight junction membrane protein
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06321913
disease_id_num_tar_ref
1958
drug_id_num_tar_ref
5240