gene_symbol
CTAG1B
hgnc_id
HGNC:2491
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered NK cells bearing an HLA-A*02:01–restricted NY-ESO-1–specific TCR recognize the NY-ESO-1 peptide–HLA complex on target cells and directly induce cytolysis via TCR-triggered perforin/granzyme (and death-receptor) pathways, with IL-15 enhancing activity and persistence.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A*02:01-restricted; canonical epitope NY-ESO-1 157–165 (SLLMWITQC)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06066359
disease_id_num_tar_ref
1962
drug_id_num_tar_ref
5247