gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti–Trop-2 antibody–drug conjugate binds Trop-2, is internalized, and releases SN-38, a topoisomerase I inhibitor that stabilizes Topo I–DNA complexes, causing DNA damage and apoptosis (with possible bystander effect).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein; antigen targeted by the hRS7 antibody moiety of the ADC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06248515
disease_id_num_tar_ref
1963
drug_id_num_tar_ref
5250