gene_symbol
HLA-DPB1
hgnc_id
HGNC:4940
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs recognize the tumor peptide–HLA-DP complex via native TCRs and directly kill target cells through perforin/granzyme release (and Fas–FasL–mediated apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC complex on tumor cells (when induced) or local APCs in the bladder
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05768347
disease_id_num_tar_ref
1965
drug_id_num_tar_ref
5252