gene_symbol
HLA-DQB1
hgnc_id
HGNC:4944
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Tumor-reactive TILs use native TCRs to recognize the tumor antigen peptide presented by HLA-DQ (pMHC II) and directly kill the presenting cells via perforin/granzyme cytotoxicity (and Fas-FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC complex on tumor cells (when induced) or local APCs in the bladder
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05768347
disease_id_num_tar_ref
1965
drug_id_num_tar_ref
5252