gene_symbol
IL12RB1
hgnc_id
HGNC:5971
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Anchored IL-12 binds IL-12 receptors (including IL12RB1) on T/NK cells to activate them; the activated effectors kill CSV-positive tumor cells, not the IL-12 receptor–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Part of IL-12 receptor heterodimer engaged by membrane-anchored IL-12
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05621668
disease_id_num_tar_ref
1967
drug_id_num_tar_ref
5254