gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 and recruits FcγR-bearing immune cells (e.g., NK cells) to mediate ADCC, killing target cells; HER2 dimerization blockade can also promote apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular dimerization subdomain II to block HER2-HER3 dimerization; IgG1 Fc enables ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06080620
disease_id_num_tar_ref
1970
drug_id_num_tar_ref
5269