gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Adoptively transferred TAA-specific CTLs recognize MAGE-A4–derived peptides on HLA class I via their TCRs and directly kill target cells by perforin/granzyme-mediated cytolysis (and Fas/FasL), with supportive cytokine effects.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA class I–restricted TCR recognition of peptide epitope
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05134740
disease_id_num_tar_ref
1972
drug_id_num_tar_ref
5275