gene_symbol
PRAME
hgnc_id
HGNC:9336
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused autologous TAA-specific CTLs recognize PRAME-derived peptides presented on HLA class I via their TCR and directly kill target cells through perforin/granzyme-mediated apoptosis (and Fas/FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA class I–restricted TCR recognition of peptide epitope
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05134740
disease_id_num_tar_ref
1972
drug_id_num_tar_ref
5275