gene_symbol
BIRC5
hgnc_id
HGNC:593
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused TAA-specific CTLs recognize Survivin peptide presented on HLA class I and directly kill target cells via TCR engagement, releasing perforin/granzymes (and ancillary Fas–FasL/cytokine-mediated apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA class I–restricted TCR recognition of peptide epitope
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05134740
disease_id_num_tar_ref
1972
drug_id_num_tar_ref
5275