gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-mediated ADCC by NK cells and other effector cells against HER2-expressing cells; additionally, HER2 dimerization blockade can induce growth inhibition and apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular subdomain II (dimerization interface); blocks HER2/HER3 dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05720026
disease_id_num_tar_ref
1973
drug_id_num_tar_ref
5277