gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and its Fc engages Fcγ receptors on NK cells/macrophages to trigger ADCC (±ADCP/CDC), killing HER2-expressing cells; signaling blockade may also promote apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV (subdomain IV) of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05720026
disease_id_num_tar_ref
1973
drug_id_num_tar_ref
5278