gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 and is internalized; lysosomal cleavage releases MMAE, which disrupts microtubules, causing G2/M arrest and apoptosis. Membrane-permeable MMAE can also cause bystander killing; Fc effector functions may contribute.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07065435
disease_id_num_tar_ref
1980
drug_id_num_tar_ref
5288