gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC48 targets HER2 on tumor cells, is internalized, and releases MMAE; MMAE then binds beta‑tubulin (vinca site) to disrupt microtubules, causing G2/M arrest and apoptosis, with possible bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca domain to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07065435
disease_id_num_tar_ref
1980
drug_id_num_tar_ref
5288