gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD19 ADC binds CD19, is internalized, and releases a PBD dimer that creates DNA interstrand cross-links, inhibiting replication and inducing cell-cycle arrest and apoptosis in the target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; internalizes upon antibody binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05660395
disease_id_num_tar_ref
1995
drug_id_num_tar_ref
5342