gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The Fc-engineered IgG1 binds CTLA-4 on target cells (e.g., intratumoral Tregs) and engages FcγR-expressing effector cells to mediate ADCC/ADCP, depleting CTLA-4–positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06268015
disease_id_num_tar_ref
2002
drug_id_num_tar_ref
5355