gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD22-specific CAR T cells bind CD22 and, upon CAR signaling, degranulate to deliver perforin/granzymes (and Fas/FasL), inducing MHC-independent apoptosis/lysis of CD22+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface B-cell antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06849921
disease_id_num_tar_ref
215
drug_id_num_tar_ref
590