gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds EGFR on tumor cells and engages Fcγ receptor–bearing immune cells, inducing ADCC and macrophage-mediated trogocytosis; this leads to direct killing of EGFR-expressing cells (in addition to receptor blockade/degradation).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; blocks ligand binding; induces receptor degradation; mediates Fc-dependent ADCC/trogocytosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05845671
disease_id_num_tar_ref
2008
drug_id_num_tar_ref
5380