gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds MET on target cells and, via its IgG1 Fc, engages Fcγ receptors on immune effectors (e.g., NK cells/macrophages) to mediate ADCC and trogocytosis/phagocytosis, killing MET-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; blocks ligand binding; induces receptor degradation; mediates Fc-dependent ADCC/trogocytosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05845671
disease_id_num_tar_ref
2008
drug_id_num_tar_ref
5380