gene_symbol
NTRK3
hgnc_id
HGNC:8033
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Entrectinib binds the ATP site of TRKC (NTRK3), inhibits its kinase activity and downstream MAPK/PI3K signaling, leading to growth arrest and apoptosis in TRKC-driven cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ATP-competitive tyrosine kinase inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05845671
disease_id_num_tar_ref
2008
drug_id_num_tar_ref
5384