gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Mosunetuzumab binds CD3ε on T cells to activate and redirect them to CD20+ B cells, forming an immune synapse. Activated T cells kill the CD20-expressing cells via perforin/granzyme-mediated cytotoxicity; CD3+ T cells are not the targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor complex subunit; T-cell engagement arm
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05849857
disease_id_num_tar_ref
2027
drug_id_num_tar_ref
5434