gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
EGFRvIII is a synNotch priming cue; binding to EGFRvIII induces CAR expression, after which T cells kill cells bearing EphA2 or IL-13Rα2 via CAR-mediated cytotoxicity (perforin/granzymes and cytokines).
enzyme_product
Off
epitope
On
variant
On
isoform
On
hla_specific
Off
gated
On
other_modifier
synNotch sensor; triggers downstream CAR expression
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186401
disease_id_num_tar_ref
2034
drug_id_num_tar_ref
5449