gene_symbol
EPHA2
hgnc_id
HGNC:3386
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Upon EGFRvIII-triggered synNotch activation, the T cells express an anti‑EphA2 CAR; CAR engagement with EphA2 on tumor cells drives T‑cell cytotoxicity via perforin/granzyme release and apoptosis-inducing pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR expression is induced only after EGFRvIII synNotch engagement (logic-gated)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186401
disease_id_num_tar_ref
2034
drug_id_num_tar_ref
5449