gene_symbol
IL13RA2
hgnc_id
HGNC:5975
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After synNotch activation by EGFRvIII, the T cells express a CAR that binds IL-13Ralpha2; CAR engagement triggers T-cell killing via immune synapse formation with perforin/granzyme release and Fas–FasL-mediated apoptosis of IL-13Ralpha2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR expression is induced only after EGFRvIII synNotch engagement (logic-gated)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186401
disease_id_num_tar_ref
2034
drug_id_num_tar_ref
5449