gene_symbol
PRAME
hgnc_id
HGNC:9336
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ImmTAC’s TCR binds the PRAME peptide–HLA-A*02:01 complex on tumor cells and its anti‑CD3 arm engages T cells, forming an immune synapse that activates T-cell cytotoxicity (perforin/granzyme and cytokine-mediated killing) of the bound target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide–MHC I complex (pHLA)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07156136
disease_id_num_tar_ref
2045
drug_id_num_tar_ref
5475