gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds PRAME peptide/HLA-A*02:01 on tumor cells and CD3 epsilon on T cells to activate T cells; the activated T cells kill PRAME-positive tumor cells, not the CD3-expressing T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
on T cells; part of TCR/CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07156136
disease_id_num_tar_ref
2045
drug_id_num_tar_ref
5475