gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 and is internalized; cleavable linker releases MMAE, a microtubule inhibitor, causing G2/M arrest and apoptosis of HER2+ cells. The IgG1 Fc can also mediate ADCC, with possible bystander killing from released MMAE.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody component binds HER2 on tumor cell surface; target selection by IHC 1+/2+/3+.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05955209
disease_id_num_tar_ref
2047
drug_id_num_tar_ref
5479