gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2, is internalized, and releases MMAE, which binds tubulin to disrupt microtubules, causing G2/M arrest and apoptosis; killing occurs after HER2-mediated uptake (and possible bystander diffusion), not by recognition of tubulin itself.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Released MMAE binds tubulin and disrupts microtubule polymerization, causing G2/M arrest and apoptosis.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05955209
disease_id_num_tar_ref
2047
drug_id_num_tar_ref
5479