gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize CD38 on target cells, form an immune synapse, and kill via perforin/granzyme-mediated lysis and apoptosis (plus Fas/FasL and cytokine-mediated effects), independent of MHC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface ectoenzyme (NADase/cADPR hydrolase) highly expressed on plasma cells/myeloma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06849921
disease_id_num_tar_ref
215
drug_id_num_tar_ref
594