gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 bnAb binds gp120 on Env-expressing infected cells and engages Fcγ receptors on NK cells/monocytes to trigger ADCC/ADCP; it can also activate complement (CDC), leading to lysis of the target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD4 binding site epitope on Env; neutralizes virions and blocks entry
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508749
disease_id_num_tar_ref
2055
drug_id_num_tar_ref
5497