gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
VRC07-523LS does not target FcRn for killing; its LS Fc mutation increases FcRn-mediated recycling to prolong half-life. Cytotoxicity (via ADCC/ADCP) is directed at HIV Env-expressing infected cells, not FcRn-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
LS Fc mutation enhances FcRn binding and extends half-life
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508749
disease_id_num_tar_ref
2055
drug_id_num_tar_ref
5497